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Fixed Drug Eruption

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My husband and I thought that it's only a birth mark but every time he has fever, the same spot gets reddish in color and gets even worst as the fever progress. When I visited my dermatologist, I asked her about this condition and she examined KIKO and was certain that fixed drug eruption (FDE) is the culprit.



What is this FDE?
A fixed drug eruption (FDE) is an adverse cutaneous reaction to an ingested drug, characterized by the formation of a solitary, but at times multiple, plaque, bulla, or erosion; if the patient is rechallenged with the offending drug, the FDE occurs repeatedly at the identical skin site (i.e., fixed) within hours of ingestion.
Causes of Fixed Drug Eruption Clearly some sort of allergy is involved but exactly how an FDE arises and in particular why just certain areas of skin are affected, has not been worked out.
Symptoms of Fixed Drug Eruption Fresh lesions are well defined, round or oval patches of redness and swelling of the skin, sometimes surmounted by a b…