"My doctors estimated that I had an 87 percent risk of breast cancer and a 50 percent risk of ovarian cancer, although the risk is different in the case of each woman. Once I knew that this was my reality, I decided to be proactive and to minimize the risk as much I could. I made a decision to have a preventive double mastectomy." (Source)
Hollywood's highest paid actress and often cited as the world's "most beautiful" woman, Angelina Jolie opted to lose her two breasts rather than lose her life to breast cancer. The decision was made upon learning that she carries a mutation of the BRCA1 gene or breast cancer susceptibility gene, which sharply increases her risk of developing breast cancer and ovarian cancer.